| Registro completo |
| Provedor de dados: |
OAK
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| País: |
Japan
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| Título: |
Artesunate, a potential drug for treatment of Babesia infection
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| Autores: |
Goo, Youn-Kyoung
Terkawi, M. Alaa
Jia, Honglin
Aboge, G. Oluga
Ooka, Hideo
Kim, Suk
Igarashi, Ikuo
Nishikawa, Yoshifumi
Xuan, Xuenan
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| Data: |
2010-09
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| Ano: |
2010
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| Palavras-chave: |
Artesunate
Babesia bovis
Babesia gibsoni
Babesia microti
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| Resumo: |
The effect of artesunate, a water-soluble artemisinin derivative, against Babesia species, such as Babesia bovis, Babesia gibsoni, and Babesia microti was studied. Cultures of B. bovis and B. gibsoni were treated with 0.26 μM, 2.6 μM, 26 μM, and 260 μM artesunate, and the growth-inhibitory effect was shown in over 2.6 μM artesunate in day 4 and day 3 post-subculture for B. bovis and B. gibsoni, respectively, in dose-dependent manner. In vivo experiment for B. microti, strong inhibition effects were observed in mouse groups treated with over 1.0 mg/kg body weight of artesunate on day 9 and 10 post-infection. These results suggest that artesunate could be a potential drug for Babesia infection.
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| Idioma: |
Inglês
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| Identificador: |
http://ir.obihiro.ac.jp/dspace/handle/10322/2820
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| Editor: |
ELSEVIER
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| Formato: |
application/pdf
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| Direitos: |
Elsevier Ireland Ltd
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